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KMID : 1094020210380010007
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Journal of Veterinary Clinics
2021 Volume.38 No. 1 p.7 ~ p.15
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Safety Evaluation of Kyungokgo-gamibang Administration Based on Hematological, Biochemical, Protein, and Lipid Profiles in Dogs
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Song Doo-Won
Lee Ga-Won
Ro Woong-Bin
Kim Heyong-Seok
Kang Hyun-Min
Kim Jong-Won
Park Soo-Bin
Moon Yang-Seon
Na Chang-Su
Park Hee-Myung
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Abstract
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Kyungokgo-gamibang, Kyungokgo with Iksuyongjingo and Sparassis crispa, is a traditional Korean medicine used for restorative effects. This study aimed to evaluate the safety of Kyungokgo-gamibang in healthy beagle dogs. In the single-dose oral toxicity study, three beagle dogs were orally administered 2,000, 1,000, and 500 mg/kg of Kyungokgo-gamibang and were observed for 14 days. In the repeated-dose oral toxicity study, nine healthy dogs were orally administered 0.2g/kg of Kyungokgo-gamibang (n = 3, low-dose group), 1 g/kg of Kyungokgo-gamibang (n = 3, high-dose group), or normal saline (n = 3, control group) twice a day for 8 weeks. The hematological, serum biochemical, urine, protein, and lipid profiles were evaluated to investigate the adverse effects of the Kyungokgogamibang. During the study period, the dogs demonstrated no clinical signs and the hematological, serum biochemical, urine, protein, and lipid analyses revealed unremarkable findings. The study results suggest that Kyungokgo-gamibang can be safely administered to dogs without any adverse effects.
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KEYWORD
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Kyungokgo-gamibang, traditional Korean medicine, safety, adverse effect, dogs
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